In this article, we’ll dive into eight common types of pills that are known to impact kidney health negatively. While these drugs can be crucial for treating various conditions, it is important to be aware of their potential side effects and understand the risks involved with their extended use.

1. Lithium – Commonly Used for Bipolar Disorder

Lithium is one of the most well-known medications used to treat bipolar disorder. It works by helping to stabilize mood and prevent manic and depressive episodes in individuals with this condition. However, while lithium can be highly effective for managing bipolar disorder, it can also have detrimental effects on kidney function when used long-term.

One of the primary concerns with lithium use is its potential to cause kidney damage, particularly when blood levels are not closely monitored. Long-term lithium use has been associated with a condition called nephrogenic diabetes insipidus, a disorder that affects the kidneys’ ability to concentrate urine. This can lead to frequent urination and dehydration, which may contribute to kidney problems over time.

Individuals taking lithium should be regularly monitored by a healthcare provider to ensure that kidney function is maintained and that blood levels of the medication stay within the therapeutic range.

2. Anticonvulsants – Phenytoin and Trimethadione

Anticonvulsants are commonly prescribed to individuals with epilepsy or other seizure disorders to help control and prevent seizures. While anticonvulsants like phenytoin and trimethadione are effective in managing seizures, they also carry the risk of kidney damage when taken for extended periods.

Phenytoin, in particular, has been linked to kidney problems, including interstitial nephritis, which is an inflammation of the kidney’s tubules and surrounding tissues. This can lead to kidney dysfunction and, in severe cases, kidney failure.

Trimethadione, though less commonly prescribed today, has also been associated with kidney toxicity. Patients on these medications should undergo routine kidney function tests to ensure that their kidneys are not being adversely affected by the treatment.

3. Chemotherapy Medications – A Group That Poses Serious Risks

Chemotherapy medications are life-saving treatments for cancer, but they come with a host of side effects, and kidney damage is among the most concerning. Certain chemotherapy drugs, including cisplatin, carboplatin, mitomycin C, and bevacizumab, are known to cause kidney toxicity.

Cisplatin, in particular, has been linked to a condition called acute kidney injury (AKI), which is a sudden decline in kidney function. This can happen during chemotherapy treatment and can be severe if not properly managed. Other chemotherapy medications, such as cyclosporine and tacrolimus, are also known to negatively impact kidney function, especially when used in high doses.

Because chemotherapy drugs target rapidly dividing cells, they can harm both cancerous and healthy cells, including those in the kidneys. Doctors carefully monitor kidney function during chemotherapy treatment, and adjustments to the dosage or medication may be necessary if kidney damage is detected.

4. Propylthiouracil – Used for Treating Thyroid Problems

Propylthiouracil (PTU) is a medication used to treat hyperthyroidism, a condition where the thyroid gland produces excess thyroid hormone. PTU helps to inhibit the production of thyroid hormones and is often prescribed to individuals with conditions like Graves’ disease.

However, prolonged use of PTU has been associated with various adverse effects, including liver and kidney damage. Although kidney damage is less common with PTU, it can occur in some patients, especially those with pre-existing kidney conditions. The medication may cause a decrease in kidney function or, in rare cases, kidney failure.

Patients taking PTU should have regular monitoring of kidney and liver function to catch any potential issues early.

5. Heartburn Relief Pills – Omeprazole, Lansoprazole, Pantoprazole, and More

Medications commonly used to treat heartburn and gastroesophageal reflux disease (GERD), such as omeprazole, lansoprazole, pantoprazole, rabeprazole, and esomeprazole, are part of a class of drugs known as proton pump inhibitors (PPIs). These medications work by reducing stomach acid production, providing relief for those suffering from acid reflux or ulcers.

However, long-term use of PPIs has been linked to kidney problems. Studies have shown that prolonged use of PPIs can increase the risk of chronic kidney disease (CKD), kidney injury, and even end-stage renal disease (ESRD) in some patients. PPIs may cause damage to the kidneys by interfering with the kidneys’ ability to filter waste products and fluid from the body.

While PPIs are effective for treating heartburn, they should not be used continuously for extended periods without consulting a healthcare provider. Patients using PPIs for more than a few weeks should discuss the risks with their doctor and have kidney function monitored.

6. Antivirals – Acyclovir, Indinavir, and Tenofovir

Antiviral medications are essential in treating viral infections such as herpes and HIV. Medications like acyclovir, indinavir, and tenofovir have been critical in controlling viral replication, but they can also have serious side effects, particularly on kidney health.

Acyclovir, used to treat herpes, can cause kidney damage in some patients, especially when taken in high doses or when the patient is dehydrated. Indinavir, an older antiviral used in HIV treatment, is known to be toxic to the kidneys, causing crystallization in the renal tubules, leading to kidney damage.

Tenofovir, a drug used for HIV and hepatitis B, has been associated with a decline in kidney function over time. Kidney damage from tenofovir can range from mild to severe, with some patients experiencing permanent kidney dysfunction.

These antiviral medications are essential for managing chronic viral infections, but patients should be monitored closely for any signs of kidney problems during treatment.

7. Captopril – A Medication for High Blood Pressure

Captopril is an angiotensin-converting enzyme (ACE) inhibitor commonly used to treat high blood pressure and heart failure. While it is an effective medication for managing blood pressure and preventing heart failure complications, it can also affect kidney function in some patients.

Captopril works by relaxing blood vessels and reducing the workload on the heart, but it can also reduce blood flow to the kidneys, especially when used in combination with other medications or in patients with pre-existing kidney conditions. In rare cases, captopril can lead to acute kidney injury or worsen existing kidney problems.

Patients on captopril should have their kidney function monitored regularly to ensure that the medication is not causing harm to their kidneys.

8. Bone and Joint Medications – Infliximab, Chloroquine, Hydroxychloroquine

Medications used to treat conditions like arthritis, lupus, and malaria can also have detrimental effects on kidney health. Infliximab, an immunosuppressant used to treat inflammatory diseases, has been linked to kidney damage, especially when used long-term.

Chloroquine and hydroxychloroquine, medications used to treat malaria and systemic lupus erythematosus, can also affect kidney function. These drugs have been shown to cause kidney problems, particularly in patients with pre-existing kidney disease.

Although these medications are necessary for managing chronic conditions, patients should be aware of the potential risks to their kidneys and discuss alternative treatments with their healthcare provider if needed.

Conclusion: Protect Your Kidneys by Being Informed

The medications listed above are commonly prescribed to manage a variety of conditions, but their long-term use can lead to kidney damage and other serious health issues. While these medications play an important role in treating illnesses, it is crucial to use them with caution and under the supervision of a healthcare provider.

If you are taking any of these medications, it’s important to have regular check-ups to monitor your kidney function and discuss any concerns with your doctor. By being proactive about your kidney health, you can reduce the risk of long-term damage and ensure that your kidneys continue to function properly for years to come. Always remember: Your kidneys play a vital role in your overall health, so take the necessary steps to protect them!